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Tianeptine Ethyl Ester

Basic information

  • Product Name:Tianeptine Ethyl Ester
  • CasNo.:66981-77-9
  • MF:
  • MW:465.013

Physical and Chemical Properties

  • Purity:99%
  • Boiling Point:
  • Packing:
  • Throughput:
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Product Details

CasNo： 66981-77-9

Reputable Factory Supply Wholesale 66981-77-9 Tianeptine Ethyl Ester with Safe Shipping

  • Molecular Formula:C23H29ClN2O4S
  • Molecular Weight:465.013
  • Boiling Point:573.3±60.0 °C(Predicted) 
  • PKA:7.44±0.20(Predicted) 
  • Density:1.30±0.1 g/cm3(Predicted) 

Tianeptine Ethyl Ester Usage

Tianeptine Ethyl Ester is an impurity of Tianeptine (T436800),an tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties

66981-77-9 Relevant articles

Tianeptine Esters Derivatives: A Study of Protein-Drug Interaction Performed by Fluorescence Quenching and Molecular Docking

FA Soares, MA Ceschi, DB Franceschini

, J. Braz. Chem. Soc. 30 (10) • Oct 2019

The nature of binding between bovine serum albumin (BSA) and the antidepressant tianeptine and a new series of esters derivatives were studied in this paper. The interactions with BSA were investigated by UV-Vis and fluorescence spectroscopy at three different temperatures. The fluorescence quenching experiments showed that BSA interactions with tianeptine could be dynamic while to its esters a static mechanism was observed.

A process for preparing 3,11-Dichloro-6-methyl -6,11-dihydrodibenzo[c,f][1,2]thiazepine 5,5-dioxide

-

Paragraph 0043-0046, (2020/10/05)

The present invention relates to a metho...

Tianeptine esters derivatives: A study of protein-drug interaction performed by fluorescence quenching and molecular docking

Soares, Franciela A.,Ceschi, Marco A.,Franceschini, Daniel B.,Do Canto, Vanessa P.,Netz, Paulo A.,Campo, Leandra F.

, p. 2125 - 2135 (2019/12/30)

The nature of binding between bovine ser...

66981-77-9 Process route

5,8-dichloro-10,10-dioxo-11-methyl-5,11-dihydrodibenzo<c,f><1,2>thiazepine
26638-66-4

5,8-dichloro-10,10-dioxo-11-methyl-5,11-dihydrodibenzo<1,2>thiazepine

7-aminoheptanoic acid ethyl ester hydrochloride
29840-65-1

7-aminoheptanoic acid ethyl ester hydrochloride

ethyl 7-((3-chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino)heptanoate
66981-77-9

ethyl 7-((3-chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino)heptanoate

Conditions
Conditions Yield
With triethylamine; In dichloromethane; for 8h; Reflux;
 
C<sub>23</sub>H<sub>27</sub>ClN<sub>2</sub>O<sub>4</sub>S

C23H27ClN2O4S

ethyl 7-((3-chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino)heptanoate
66981-77-9

ethyl 7-((3-chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino)heptanoate

Conditions
Conditions Yield
With 5%-palladium/activated carbon; ammonium formate; In methanol; at 20 ℃; for 12h;
 

66981-77-9 Upstream products

  • 191172-75-5
    191172-75-5

    tianeptine

  • 64-17-5
    64-17-5

    ethanol

  • 26638-53-9
    26638-53-9

    8-chloro-10,10-dioxo-11-methyl-5,11-dihydrodibenzo<1,2>thiazepin-5-one

  • 1117-66-4
    1117-66-4

    7-aminoheptanoic acid ethyl ester

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